Researcher ID profile can be found at:

List of Publications:

Yee, RE; Huang, SC; Stout, DB; Irwin, I; Shoghi-Jadid, K; Togaski, DM; DeLanney, LE; Langston, JW; Satyamurthy, N; Farahani, KF; Phelps, ME; Barrio, JR. Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: In vivo and in vitro investigations. Journal of Neurochemistry, 2000, V74(N3):1147-1157

K. Shoghi-Jadid* , S-C Huang, DB Stout, RE Yee, EL Yeh, KF Farahani, N Satyamurthy, ME Pehlps, nad JR Barrio (2000). Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution volume of 3OMFD: A positron emission tomography (PET) investigation using non-human primates, Journal of Cerebral Blood Flow and Metabolism, 20, 1134-1148

Yee RE, Irwin I, Milonas C, Stout DB, Huang SC, Shoghi-Jadid K, Satyamurthy N, Delanney LE, Togaski DM, Farahani KF, Delfani K, Janson AM, Phelps ME, Langston JW, Barrio JR, Novel observations with FDOPA-PET imaging after early nigrostriatal damage, Movement Disorders, 16(5): 838-848, Sep, 2001

Shoghi-Jadid K*, Small GW, Agdeppa ED, Keppe V, Ercoli L, Siddarth P, Satyamurthy N, Petric A, Huang S-C, Barrio JR (2002). Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Living Brain of Alzheimer’s Disease Patients, Journal American of Geriatric Psychiatry, 10(1): 24-35.

Agdeppa ED, Kepe V, Shoghi-Jadid K, Liu J, Small GW, Huang SC, Petric A, Satyamurthy N, Barrio JR, 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer’s disease (2003), Mol Imaging Biol, 5(6) 404-417

Sung-Cheng Huang; Hsiao-Ming Wu; Shoghi-Jadid, K.; Stout, D.; Chatziioannou, A., Statistical tests for discriminating inaccurate input functions in dynamic mouse microPET studies, Nuclear Science Symposium Conference Record, 2003 IEEE, Volume 4, 19-25 Oct. 2003 Page(s):2853 – 2857 Vol.4

Huang SC, Wu HM, Shoghi-Jadid K, Stout DB, Chatziioannou A, Schelbert HR, Barrio JR (2004). Investigation of a new input function validation approach for dynamic mouse microPET studies, Mol Imaging Biol. 6(1) 34-46

Shoghi-Jadid K*, Barrio JR, Kepe V, Wu HM, Small GW, Phelps ME, Huang S-C, Imaging beta-Amyloid Fibrils in Alzheimer’s Disease: A Critical Analysis through Simulation of Amyloid Fibril Polymerization (2005), Nuc Med Biol 32(4):337-351.

Kepe V, Barrio JR, Huang SC, Ercoli L, Siddarth P, Shoghi-Jadid K, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME, Serotonin 1A receptors in the living brain of Alzheimer’s disease patients. Proc Natl Acad Sci USA 2006;103(3):702-7.

Wu HM, Kreissl MC, Schelbert HR, Ladno W, Prins M, Shoghi-Jadid K, Chatziioannou AF, Phelps ME, Huang SC: First-pass angiography in mice using FDG-PET: A simple method of deriving the cardiovascular transit time without the need of region-of-interest drawing. IEEE Transactions on Nuclear Science, 2005; 52(5):1311-1315

Hsiao-Ming Wu; Kreissl, M.C.; Schelbert, H.R.; Ladno, W.; Prins, M.; Shoghi-Jadid, K.; Chatziioannou, A.; Phelps, M.E.; Sung-Cheng Huang, First-pass angiography in mice using FDG-PET: a simple method of deriving the cardiovascular transit time without the need of region-of-interest drawing, IEEE Transactions on Nuclear Science, Volume 52, Issue 5, Page(s):1311 – 1315

Shoghi-Jadid K*, Barrio JR, Kepe V, Huang S-C, Exploring Mathematical Models for the Kinetics of beta-Amyloid Molecular Imaging Probes through a Critical Analysis of beta-Amyloid Plaque Pathology, Molecular Imaging and Biology, 2006; 8(3):151-162

Shoghi, Kooresh* I.; Rowland, Douglas J.; Laforest, Richard; Welch, Michael J., Characterization of Spillover and Recovery Coefficients in the Gated Mouse Heart for Non-Invasive Extraction of Input Function in microPET Studies: Feasibility and Sensitivity Analysis, IEEE Transactions on Nuclear Science, 2006., Volume 4, Oct. 2006 Page(s):2134 – 2136

Su Y, Welch MJ, Shoghi KI*, The application of maximum likelihood factor analysis (MLFA) with uniqueness constraints on dynamic cardiac microPET data, Phys Med Biol., 2007; 52(8): 2313-34
Shoghi KI*, Welch MJ, Hybrid Image-Blood-Sampling Input Function for Quantification of microPET Data, Nuc. Med. Biol., 34(8): 989-994, 2007

Li H, Thostad W, Biehl K, Laforest R, Su Y, Shoghi K, Donnelly E, Low D, Lu W, A PET head and neck tumor delineation approach based on mumford-shah active contours, Medical Physics, 34( 6): 2351-2351, 2007

Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Shoghi K, Welch MJ, and Kelly DP, The Nuclear Receptors PPARβ/δ and PPARα Direct Distinct Overlapping Cardiac Gene Regulatory Programs, Journal Clinical Investigation, 117(12): 3930-3939, 2007

Shoghi KI*, Finck BN, Sharp T, Herrero P, Fettig N, Su Y, Kovacs A, Gropler RJ, Welch MJ, Time-Course of Alterations in Myocardial Glucose Utilization in the Zucker Diabetic Fatty (ZDF) Rat with Correlation to Gene Expression of Glucose Transporters: A Small Animal PET Investigation, J. Nuc. Med., 49(8):1320-7, 2008

Su, Y; Welch, MJ; Shoghi KI*, Single Input Multiple Output (SIMO) Optimization for Input Function Estimation: A Simulation Study, IEEE Transactions on Nuclear Science, pp. 4481-4, 2007

Li H, Thorstad WL, Biehl KJ, Laforest R, Su Y, Shoghi KI, Donnelly ED, Low DA, Lu W, A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours, Med. Physics, 35(8): 3711-3721, 2008

Yi Su, and Kooresh I. Shoghi*, ROI Based Input Function Estimation with Deconvolution Based Partial Volume Correction for Small Animal PET Dataset: A Simulation Study, IEEE Transactions on Nuclear Science, 2008

Yi Su and Kooresh I Shoghi*, Wavelet denoising in voxel-based parametric estimation of small animal PET images: a systematic evaluation of spatial constraints and noise reduction algorithms, Phys. Med. Biol. 53: 5899-5915, 2008

Shoghi KI*, Finck BN, Schechtman KB, Sharp T, Herrero P, Gropler RJ, and Welch MJ, In Vivo Metabolic Phenotyping of Myocardial Substrate Metabolism in Rodents: Differential Efficacy of Metformin and Rosiglitazone Monotherapy, Circulation Cardiovasc Imaging. 2009 Sep;2(5):373-81

Kooresh Shoghi*, Quantitative Small Animal PET Imaging in Drug Discovery, Q J Nucl Med Mol Imaging. 2009 Aug;53(4):365-73

Yi Su, and Kooresh I. Shoghi*, Single-Input-Dual-Output Modeling of Image-Based Input Function Estimation, Mol Imaging Biol, 2(3):286-294, 2010

Ryan E. Tomlinson, Matthew J. Silva, and Kooresh I. Shoghi*, Quantification of Skeletal Blood Flow and Fluoride Metabolism in Rats using PET in a Pre-Clinical Stress Fracture Model, Mol Imaging Biol, Jun;14(3):348-54, 2012

Tu Z, Fan J, Li S, Jones LA, Cui J, Padakanti PK, Xu J, Zeng D, Shoghi KI, Perlmutter JS, Mach RH., Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain, Bioorg Med Chem. 2011 Mar 1;19(5):1666-73

F. Dehdashti, R.Laforest, F.Gao, R.L.Aft, C.S.Dence, D.Zhou, K.I.Shoghi, B.A. Siegel, J.A. Katzenellenbogen, M. J. Welch, Assessment of Progesterone Receptors in Breast Carcinoma by Positron Emission Tomography with 21-[18F]Fluoro-16α,17α-[(R)-1′-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione (FFNP), J Nuc Med 2012; 53:363-370.

J.C. Cheng, K. Shoghi, R.Laforest, Quantitative Accuracy of MAP Reconstruction for Dynamic PET Imaging in Small Animals, Med. Phys., 2012; 39(2):1029-1041.

Herrero P, Laforest R, Shoghi K.I, Zhou D, Ewald G, Pfeifer J, Duncavage E, Krupp K, Mach R.H , Gropler R.J, Feasibility and dosimetry studies for [18F]NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase (iNOS) in humans, J Nuc Med 2012; 53: 994-1001

Timothy D. Whitehead, Samuel T. Nemanich, and Kooresh I. Shoghi*, Artificial Tissue Bioreactor (ATB) for Biological and Imaging Applications, IEEE Eng Med Biol. 2012;2012:2420-3

Solingapuram Sai, K. K., Kil, K. E., Tu, Z., Chu, W., Finck, B. N., Rothfuss, J. M., Shoghi, K. I., Welch, M. J., Gropler, R. J., Mach, R. H., Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-alpha receptors, Bioorg Med Chem Lett; 2012, 22(10):6233-6236

Dehdashti, F., Laforest, R., Gao, F., Aft, R. L., Dence, C. S., Zhou, D., Shoghi, K. I., Siegel, B. A., Katzenellenbogen, J. A., Welch, M. J. Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16alpha,17alpha-[(R)-(1′-alpha-furylmethylidene)dioxy]-19-norpregn- 4-ene-3,20-dione, J Nuc Med, 2012, 53(3):363-370

Sudheer D. Rani, Samuel T. Nemanich, Kooresh I. Shoghi*, Kinetic analysis of FDG in rat liver: contribution of the hepatic artery and portal vein, Nuc Med Bio, May 2013; 40(4):537-46

Jeho Jeong, Kooresh I. Shoghi, Joseph O. Deasy, Modelling the interplay between hypoxia and proliferation in radiotherapy tumour response, Phys Med Biol. 2013 Jul 21;58(14):4897-919

Samuel Nemanich, Sudheer Rani, Kooresh Shoghi*, In Vivo Multi-Tissue Efficacy of PPAR Therapy on Glucose and Fatty Acid Metabolism in Obese Type 2 Diabetic Rats, Obesity 2013, 21(12):2522-2529

Farrokh Dehdashti, Richard Laforest, Feng Gao, Kooresh I. Shoghi, Rebecca L. Aft, Brian Nussenbaum, Friederike H. Kreisel, Nancy L. Bartlett, Amanda Cashen, Nina Wagner-Johnson, Robert H. Mach, Assessment of Cellular Proliferation in Tumors by Positron Emission Tomography (PET) Using [18F]ISO-1, J Nucl Med. 2013 Mar;54(3):350-7

Timothy D. Whitehead, Samuel T. Nemanich, Carmen Dence, Kooresh I. Shoghi*, A PET Compatible Tissue Bioreactor for Research, Discovery, and Validation of Imaging Biomarkers and Radiopharmaceuticals: System Design and Proof-of-Concept Studies, J Nucl Med. 2013 Oct;54(10):1812-9

Kooresh I Shoghi*, Jinbin Xu, , Yi Su, Jun He, Douglas Rowland ,Ying Yan, Joel R Garbow, Zhude Tu, Lynn Jones, Kenneth T. Wheeler, Ronald A Lubet, Robert H Mach, Ming You, Quantitative Receptor-based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1, PLoS One. 2013 Sep 20;8(9):e74188

Sriram Devanathan, Samuel T. Nemanich, Attila Kovacs, Nicole Fettig, Robert J. Gropler, Kooresh I. Shoghi*, Genomic and metabolic disposition of non-obese type 2 diabetic rats to increased myocardial fatty acid metabolism, PLoS One. 2013 Oct 21;8(10):e78477

Ryan Tomlinson, Kooresh I. Shoghi, and Matt Silva, Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing, J Appl Physiol (1985). 2014 Feb 15;116(4):416-24

Wenhua chu, Andre Chepetan, Dong Zhou, Kooresh I Shoghi, Jinbin Xu, Laura L Dugan, Robert J Gropler, Mark A Mintun and Robert Henry Mach, Development of a PET Radiotracer for Noninvasive Imaging of the Reactive Oxygen Species, Superoxide, in vivo, Organic & Biomolecular Chemistry, Org Biomol Chem. 2014 Jun 4;12(25):4421-31

Sriram Devanathan, Timothy Whitehead, George G. Schweitzer, Nicole Fettig, Attila Kovacs, Kenneth S. Korach, Brian N. Finck, Kooresh I. Shoghi, An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: Functional, metabolic, and differential network analysis, PLoS One. 2014 Jul 7;9(7):e101900

Shoghi, K.I.; Gropler, R.J., PET Measurements of Organ Metabolism: The Devil Is in the Details, Diabetes 64(7) 2332-2334